ACYLATED ALCANOLAMIDES OF LYSERGINIC ACID DISPLAYING NEOTROPIC ACTIVITY

摘要

Processes for the synthesis of acylated lysergic acid alkanolamides of the formula I, which can be used for the therapy of all sorts of forms of reduced cerebral ability, in particular the age-related manifestations, are described. The preparation of I is carried out according to the invention either by acylation of the lysergic acid diethanolamides IV or lysergic acid ethanolamides V occurring as intermediates in a conventional manner, for example by means of a reactive acid derivative in pyridine or by coupling of an appropriate lysergic acid II, which has previously been converted into an activated form, with an already acylated amine VII. Finally, I unsubstituted in the 2-position can be converted into 2-halogenated derivatives using a mild halogenating agent, such as, for example, N-bromosuccinimide in dichloromethane.