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ISOLATION OF ALOE-EMODIN

机译:芦荟大黄素的分离

摘要

Anthraquinone derivatives of the formula IMAGE where at most two of R originate from the group comprising H, CH3, C2H5 and C3H7, but at least two of R originate from the group comprising the substituents OH, CH2OH, C2H4OH, the esters of these substituents with carboxylic acids having at most 3 C atoms or the glycosides of these substituents, where a plant containing the anthraquinone derivative or an extract of this plant is extracted by means of a solvent - in particular at elevated temperature - are prepared by the following process: a) the plant or extract is extracted by means of a first hydrophilic solvent, in particular by means of water, an alcohol having a maximum of 3 C atoms, acetone, ethyl acetate, diethyl acetate [sic], or mixtures of these solvents and the extract is then filtered; b) the resulting solution is either evaporated - preferably to a residual content of at least 5, in particular to 10 to 15 per cent by weight of solvent to a syrupy consistency - or passed through a polar ion exchanger, for example Amberlite IR45, from which the retained anthraquinone derivatives are eluted using methanol; c) the compound is extracted from the syrup by means of a second solvent, in particular benzene and/or a homologue thereof, which step is preferably repeated 2 to 4 times with the residue from the extraction; d) the extract is evaporated to dryness and optionally recrystallised. The filtrate resulting after step a) can be exposed to air and light for several days - in particular several times successively - before step b), preferably with stirring and/or introduction of oxygen and/or with UV irradiation.
机译:的蒽醌衍生物,其中R的至多两个源自H,CH3,C2H5和C3H7,而R的至少两个源自取代基OH,CH2OH,C2H4OH,这些酯通过以下方法制备含有至多3个碳原子的羧酸的取代基或这些取代基的糖苷,其中通过溶剂特别是在高温下通过溶剂提取含有蒽醌衍生物的植物或该植物的提取物。 :a)植物或提取物是通过第一亲水性溶剂提取的,尤其是用水,具有最多3个C原子的醇,丙酮,乙酸乙酯,乙酸二乙酯[sic]或这些溶剂的混合物提取然后将提取物过滤; b)蒸发所得溶液-优选至残留溶液的至少5%,特别是至糖浆稠度的溶剂重量的10%至15%-或通过极性离子交换剂,例如Amberlite IR45用甲醇洗脱保留的蒽醌衍生物; c)通过第二种溶剂,特别是苯和/或其同系物,从糖浆中提取化合物,该步骤优选与提取物中的残留物重复2-4次; d)将萃取物蒸发至干并任选地重结晶。在步骤b)之前,优选在搅拌和/或引入氧气和/或通过UV辐射的情况下,将步骤a)之后得到的滤液暴露于空气和光中数天,尤其是连续数次。

著录项

  • 公开/公告号GB8829782D0

    专利类型

  • 公开/公告日1989-02-15

    原文格式PDF

  • 申请/专利权人 GAMUT INTERNATIONAL INC;

    申请/专利号GB19880029782

  • 发明设计人

    申请日1988-12-21

  • 分类号C07C46/00;C07C50/34;

  • 国家 GB

  • 入库时间 2022-08-22 06:29:20

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