首页> 外国专利> DRUG FOR INCREASING ADENOSINE 5'-TRIPHOSPHATE LEVEL IN BLOOD AND PLASMA CONTAINING ADENINE NUCLEOTIDE AS EFFECTIVE COMPONENT

DRUG FOR INCREASING ADENOSINE 5'-TRIPHOSPHATE LEVEL IN BLOOD AND PLASMA CONTAINING ADENINE NUCLEOTIDE AS EFFECTIVE COMPONENT

机译:提高血液和血浆中腺嘌呤核苷酸作为有效成分的腺苷5'-磷酸根水平的药物

摘要

PURPOSE: To obtain the subject medicine containing adenosine5'-monophosphate or a derivative thereof as an active ingredient, capable of suppressing the growth of and destructing tumor cells without attacking normal cells. CONSTITUTION: This medicine contains adenosine5'-monophosphate, a pharmaceutically permissible salt thereof, a chelate thereof or a radioactive nucleus kind thereof, and further adenosine5'-diphosphate and/or adenosine5'-triphosphate as an active ingredient, and can increase the adenosine5'-triphosphate level in the blood or plasma of a host to suppress the growth of tumor cells. The medicine can also substantially suppress the body weight loss caused by a cancer cachexia. The administering amount of the active ingredient is in 1-1000mg/kg body weight range in the case of an oral or a local administration, and in the case of an intravenous, an intraperitoneal or an intraarterial administration, it is preferable to administer a dose of 1-1000mg/kg body weight at a rate of 0.001-15mg/kg body weight.
机译:目的:获得包含腺苷5'-单磷酸酯或其衍生物作为有效成分的主题药物,其能够抑制肿瘤细胞的生长并破坏肿瘤细胞而不会攻击正常细胞。组成:该药物含有腺苷5'-单磷酸酯,其药学上可接受的盐,其螯合物或放射性核素,并进一步包含腺苷5'-二磷酸和/或腺苷5'-三磷酸作为有效成分,并能增加腺苷5'血液或宿主血浆中的三磷酸水平可抑制肿瘤细胞的生长。该药物还可以基本上抑制由癌症恶病质引起的体重减轻。在口服或局部给药的情况下,活性成分的给药量为1-1000mg / kg体重的范围,在静脉内,腹膜内或动脉内给药的情况下,优选给药剂量。以0.001-15mg / kg体重的速率服用1-1000mg / kg体重。

著录项

  • 公开/公告号JPH02111724A

    专利类型

  • 公开/公告日1990-04-24

    原文格式PDF

  • 申请/专利权人 ERIIZAA RAPAPOOTO;

    申请/专利号JP19890190377

  • 发明设计人 ERIIZAA RAPAPOOTO;

    申请日1989-07-22

  • 分类号A61K31/70;A61K31/7042;A61K31/7052;A61K31/7076;A61P35/00;C07H19/20;

  • 国家 JP

  • 入库时间 2022-08-22 06:25:16

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