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Utilization of adenine nucleotides and/or adenosine and inorganic phosphate for elevation of liver, blood and blood plasma adenosine 5'- triphosphate concentrations

机译:利用腺嘌呤核苷酸和/或腺苷和无机磷酸盐提高肝脏,血液和血浆中腺苷5'-三磷酸盐的浓度

摘要

Administration of adenine nucleotides to a host is followed by their rapid degradation to adenosine and inorganic phosphate which promote increases in liver ATP pools. The turnover of expanded liver ATP pools supply the adenosine precursor for the subsequent expansions of red blood cell (total blood) and blood plasma (extracellular) ATP pools. Thus, the administration of AMP, ATP or their degradation products adenosine and inorganic phosphate to a host, achieve the beneficial increases in liver, total blood and blood plasma ATP levels.
机译:向宿主施用腺嘌呤核苷酸后,它们会迅速降解为腺苷和无机磷酸盐,从而促进肝脏ATP库的增加。扩展的肝脏ATP池的周转量为随后的红细胞(全血)和血浆(细胞外)ATP池的扩展提供了腺苷前体。因此,向宿主施用AMP,ATP或其降解产物腺苷和无机磷酸盐可实现肝脏,全血和血浆ATP水平的有益增加。

著录项

  • 公开/公告号US5227371A

    专利类型

  • 公开/公告日1993-07-13

    原文格式PDF

  • 申请/专利权人 RAPAPORT;ELIEZER;

    申请/专利号US19890400547

  • 发明设计人 ELIEZER RAPAPORT;

    申请日1989-08-31

  • 分类号A61K31/70;

  • 国家 US

  • 入库时间 2022-08-22 04:58:04

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