DNA SEQUENCE CODING HUMAN IXTH FACTOR OR SIMILAR PROTEIN, EXPRESSIVE VECTOR, TRANSFORMED CELL, PREPARATION OF IXTH FACTOR AND OBTAINED CORRESPONDING PRODUCT

摘要

The present invention relates to a novel DNA sequence coding for factor IX or an analogous protein, corresponding to a prosequence and to factor IX or to the mature analogous protein. According to the invention, the position (-3) in the prosequence is occupied by a codon coding for valine, arginine, lysine, threonine or serine and/or the first codon of the sequence coding for the mature protein codes for an alanine. Application to the expression of active factor IX in mammalian cells.