DNA SEQUENCE CODING FOR THE HUMAN IX FACTOR OR A SIMILAR PROTEIN, EXPRESSION VECTOR, TRANSFORMED CELLS, PROCESS FOR THE PREPARATION OF IX FACTOR AND PRODUCTS OBTAINED

摘要

The present invention relates to a new DNA sequence encoding factor IX or an analogous protein, corresponding to a prosequence and to factor IX or the mature analogous protein. According to the invention, position (-3) in the prosequence is occupied by a codon coding for valine, arginine, lysine, threonine or serine and / or the first codon of the sequence coding for the mature protein. code for an alanine. Application to the expression of active factor IX in mammalian cells.