METHOD OF 2-SUSBSTITUTED 2-(OMEGA-QUANIDINO-ALKAMIDO,OMEGA-QUANDINO-ALKENAMIDO AND OMEGA-QUANIDINO-HYDROXYALKAMISO-N-(4-(3-AMINOPROPYL)AMINOBUTYL(ERGANAMIDES AND TEIR SALTS PRODUCTION

摘要

N-[4-(3-Aminopropyl)aminobutyl]-2-( omega -guanidino-fatty acid-amido)-2-substituted-ethanamides represented by the general formula IMAGE I wherein Y represents -(CH2-CH2-, -CH=CH or IMAGE R represents a hydrogen atom, an alkyl group of 1 to 4 carbon atoms which may have a hydroxyl group as substituent, or a benzyl group, and n is an integer of from 1 to 8, provided that when Y is IMAGE and n is 4, R represents the groups other than the hydrogen atom; a salt thereof having antitumor activity in experimental animal tumors and a process for the preparation thereof is provided.