Process for the preparation of a vaccine against flu virus containing a vaccinal polypeptide and such polypeptide

摘要

This invention relates to a process for the preparation of a vaccine to stimulate protection against infection by flu virus in animals. The process comprises associating a polypeptide having an immunogenic determinant in the region bounded by amino acid 64 and amino acid 222 of the HA2 subunit of the HA protein in the flu virus, fused to a polypeptide which causes the said amino acids to adopt an immunogenic configuration, with a vehicle of diluent and optionally with an adjuvant, the polypeptide being optionally freeze dried, containing a single dose of vaccine of approximately 1 to 100 micrograms of polypeptide. The invention also relates to a process for preparing such polypeptides.