ABSTRACTImproved methods of anesthesia for mammals, especiallyhumans, are provided wherein the prolonging effect upon localanesthesia which is exhibited by co-administration ofvasoconstrictors, especially vasoconstrictors believed to actupon alpha adrenoreceptor sites on blood vessel walls, areprovided. In accordance with a preferred embodiment, alphaadrenoreceptor blocking agents are administered subsequent tothe performance of surgery or dentistry under local anesthesiaaccomplished through co-administration of anesthesia andvasoconstrictor to cause reduction of prolonged anestheticeffect. Seriatim procedures are facilitated under localanesthesia through employment of the present invention.Improved patient aesthetics, diminution of self-inflictedtrauma, and increased sensory feedback from patients are amongthe benefits conferred by the present invention.
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