The invention relates to a usable syringe and once by immobilization of the plunger after a first use. It consists of a syringe body (1) equipped with a nut (3) provided with a piston locking device (5) having two racks in opposite directions. When the user has filled the syringe by suction with the piston (5), it exerts a pressure in order to start the ejection of the liquid. The spacer ring (4) is driven, releasing the locking device. It is then impossible to refill the syringe. The syringe of the invention is particularly useful against the spread of certain diseases by use of contaminated needles.
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