process for the production of the 4 '- chloro - 2 - 3 - (10.11 - dihydro - 5h - dibenz (b, f) azepin - 5 - yl) - propyl - methylamino} - acetophenon - hydrochlorids (lofepramin hydrochloride)

摘要

The present invention relates to a new and improved method for the preparation of the hydrochloride of 4'-chloro-2-{(3-(10,11-dihydro-5H-dibenz[b,f]azepinyl-(5))-propyl)-met hyl-amino}-acetophenone, in the following called lofepramine hydrochloride. In the following, the free base is referred to as lofepramine.