process for the preparation of 4 '- chloro -, hydrochloride (10,11 - dihydro - 5h dibenz (b, f)) azepinyl - (5) - propyl) - methylamino - acetophenone (or lofepramine hydrochloride)

摘要

The present invention relates to a new and improved method for the preparation of the hydrochloride of 4'-chloro-2-{(3-(10,11-dihydro-5H-dibenz[b,f]azepinyl-(5))-propyl)-met hyl-amino}-acetophenone, in the following called lofepramine hydrochloride. In the following, the free base is referred to as lofepramine.