17 ALPHA-ALKYNE-17 BETA-HYDROXY-1 ALPHA- METHYL-4-ANDROSTENE-3-ONE, MANUFACTURE AND MEDICINE HAVING ANTI-ANDROGENIC ACTIVITY AND FAT PRODUCTION INHIBITING ACTIVITY

摘要

17 alpha -Alkyl-17 beta -hydroxy-1 alpha -methyl-4-androsten-3-ones of the formula IMAGE wherein R is a straight-chain alkyl residue of 3-8 carbon atoms, i.e., C3-8-n-alkyl, are pharmacologically active compounds distinguished by antiandrogenic activity, especially upon topical application.