METHOD FOR PREPARING PHARMACEUTICAL PREPARATIONS WITH DIURETIC AND URICOSURIC ACTION, AND METHOD FOR PREPARING FOR USE THEREOF 5- (1-OXO-METHYL-METHYL-5-METHYL) METHYL-METHYL-METHYL-METHYL-METHYL

摘要

1474460 Indanones MERCK & CO Inc 7 Oct 1974 [11 Oct 1973 30 July 1974] 26849/76 Divided out of 1474459 Heading C2C The invention comprises compounds of formula wherein R‹ is (a) Ph optionally substituted by NO 2 , OH, C 1-5 alkyl or alkoxy, cycloalkyl, halogen, NH 2 , CN, SO 2 , NH 2 , SO 2 Me or SO 2 Cl, or (b) thienyl optionally substituted by C 1-5 alkyl and/or halogen; R* is H, C 1-5 alkyl or aralkyl; A is O or S; R is (up to C 5 ) alkyl or alkenyl, Ph-C 1-3 alkyl, Ph-C 3-5 alkenyl, aryl (possibly substituted), cycloalkyl or cycloalkyl-C 1-5 alkyl, and RSP1/SP is H, C 1-5 alkyl or aryl, or R-RSP1/SP is a C 1-4 bivalent hydrocarbon chain; XSP1/SP is H, Z or Me and XSP2/SP is Z, Me or CZ 3 (where Z = halogen), or XSP1/SP-XSP2/SP is a C 3-4 bivalent hydrocarbon chain. In examples, these compounds are prepared by (i) introducing the substituent R‹ or R, (ii) converting the compound where R*A is MeO to the corresponding phenol, or (iii) introducing a CN or NO 2 group into the Ph ring represented by R‹. Details are given for the preparation of 2,2SP1/SP-dithienyl iodonium chloride and its substituted analogues. It is stated that certain compounds of the invention have diuretic, saluretic and uricosuic activity.