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HUMAN AND BOVINE ACIDIC FIBROBLAST GROWTH FACTOR VECTORS, HOSTS AND COMPOSITIONS
HUMAN AND BOVINE ACIDIC FIBROBLAST GROWTH FACTOR VECTORS, HOSTS AND COMPOSITIONS
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机译:人和牛酸性成纤维细胞生长因子矢量,宿主和组成
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摘要
Unique genes coding for the amino acid sequence of bovine acidic fibroblast growth factor (aFGF) and human aFGF are constructed. The bovine gene is derived from reverse translation of the aFGF amino acid sequence while the human gene is derived by specific point mutations of the bovine gene. Each gene construct is inserted into an expression vector which is used to transform an appropriate host. The transformed host cells produce recombinant aFGF (r-aFGF), human or bovine, which is purified and has an activity equivalent to the native protein.
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