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PHARMACEUTICAL COMPOSITION COMPRISING A DIVALENT METAL SALT COMPLEX OF INDOMETHACIN, AND METHOD OF TREATING INFLAMMATION AND PAIN
PHARMACEUTICAL COMPOSITION COMPRISING A DIVALENT METAL SALT COMPLEX OF INDOMETHACIN, AND METHOD OF TREATING INFLAMMATION AND PAIN
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机译:包含吲哚美辛不同金属盐配合物的药物组合物以及治疗发炎和疼痛的方法
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摘要
The present invention provides a method for the treatment of inflammation and pain in a mammal requiring such treatment, comprising administering to said mammal an anti-inflammatory and analgesically effective amount of an indomethacin salt of a divalent metal capable of forming a stable complex with indomethacin, or of a pharmaceutical composition comprising said indomethacin salt together with a pharmaceutically acceptable carrier, diluent and/or excipient. The present invention also provides a process for the preparation of an indomethacin salt of a divalent metal capable of forming a stable complex with indomethacin comprising forming a solution by dissolving indomethacin and a salt of said divalent metal in a tertiary amide or cyclic tertiary amide, adding a C1-4 alkanol or C3-6 ketone to the solution to precipitate the indomethacin metal salt and separating the indomethacin metal salt precipitate from the solution. The present invention still further provides a pharmaceutical composition for alleviating inflammation and pain comprising an anti-inflammatory and analgesically effective amount of salts of indomethacin produced by the process of the invention together with a pharmaceutically acceptable carrier, diluent and/or excipient.
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