PEPTIDE INHIBITORS OF HUMAN PAPILLOMA VIRUS PROTEIN BINDING TO RETINOBLASTOMA GENE PROTEINS

摘要

41/RJN17995IATITLE OF THE INVENTIONPEPTIDE INHIBITORS OF HUMAN PAPILLOMA VIRUS PROTEINBINDING TO RETINOBLASTOMA GENE PROTEINSABSTRACT OF THE INVENTIONThe present invention comprises biochemicallypure polypeptides, identified from the human Papillomavirus (HPV) E7 protein, which efficiently block thebinding of the HPV E7 protein to the protein encodedby the retinoblastoma gene (RBG). The polypeptidesare antagonists of the biochemical interaction of theHPV E7 protein and the RBG protein. The invention isuseful in the treatment of genital warts and cervicalcancer. One polypeptide of the present invention(Peptide A) has an amino acid sequence of:Thr-Asp-Leu-Tyr-Cys-Tyr-Glu-Gln-Leu-Asn-Asp-Ser-Ser.