PROCESS FOR THE PREPARATION OF (PYRIDYL-3)-2 TETRAHYDROTHIOPYRANECARBOTHIOAMIDE-2-OXYDES-1-(1R,2R), (PYRIDYL-3)-2 TETRAHYDROTHIOPYRANECARBOTHIOAMIDE-2-OXYDES-1-(1R,2R) THUS OBTAINED AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE

摘要

PATENT PREPARATION PROCESS (PYRIDYL-3) -2 TETRAHYDROTHIOPYRANNECARBOTHIOAMIDE-2-OXIDE-1- (1R, 2R), THE (PYRIDYL-3) -2 TETRAHYDROTHIOPYRANNECARBOTHIOAMIDE-2-OXIDE-1- (1R, 2R) AND THEREBY Compositions PHARMACEUTICAL CONTAINING HEALTH Rhone-Poulenc SHORT A process for preparing (3-pyridyl) -2-tétrahydrothio pyrannecarbothioamide-2-oxide-1- (1R, 2R) of general formula: (R1 = alkyl containing 1 to 4 carbon atoms) by reacting an isothiocyanate of alkyl sulfoxides 1R, 2R and 1R, 2S of the formula: taken alone or as a mixture, (3-pyridyl) -2-tétrahydropyrannecar bothioamide-2-oxide-1- (1R, 2R) thus obtained and pharmaceutical compositions containing them. The (3-pyridyl) -2 tétrahydrothiopyrannecarbothioamide-2-oxide-1- (1R, 2R) are particularly useful as anti-hyper-tensors.