HETEROCYCLYL OLEFINIC COMPOUNDS USEFUL IN PHARMACEUTICAL AND VETERINARY COMPOSITIONS

摘要

The use of an olefinic compound of the formula R1R2R3C-CR4 = CR5R6 (I), wherein R1 is a heterocyclyl radical selected from 1,2,4-triazolyl, imidazolyl, 5-(1-6C alkyl)imidazol-1-yl, pyridyl and pyrimidinyl; R2 and R3, which may be the same or different, are each a hydrogen atom or a 1-6C alkyl radical; R4 is a phenyl or pyridyl radical, optionally bearing one or more substituents selected from halogen atoms, amino, cyano, carbamoyl and nitro radicals, 1-6C alkyl, halogenoalkyl, alkoxy, halogenoalkoxy, alkylamino and alkylcarbamoyl radicals, di(1-6C alkyl)amino, di(1-6C alkyl)carbamoyl and 2-6C alkoxycarbonyl radicals; R5 is a hydrogen or halogen atom, a 1-6C alkyl radical or a phenyl radical optionally bearing one or more substituents as defined above for R4; and R6 is a phenyl or pyridyl radical optionally bearing one or more substituents as defined above for R4; or, for those compounds which contain a basic nitrogen atom, the pharmaceutically or veterinarily acceptable salts thereof, for the manufacture of a pharmaceutical or veterinary composition having utility as an aromatase inhibitor.