Intraocular pressure reducing 15-acyl prostaglandins

摘要

The invention provides ophthalmic compositions for reducing ocular hypertension comprising an ophthalmically acceptable excipient and at least one compound of the formula: wherein the dotted lines represent a single bond, or a double bond in the cis or trans configuration; A is OH or a pharmaceutically acceptable salt thereof or OR₅; R₁ and R₂ combined are -OH/-OH, =O/-OH, or -OH/=O; R₃ is an acyclic hydrocarbon, saturated or unsaturated, having from 1 to 20 carbon atoms, or R₃ is -(CH₂)_nR₄ where n is 0-10; R₄ is an aliphatic ring from 3 to 7 carbon atoms or an aromatic or heteroaromatic ring; and R₅ is an aliphatic radical of from 1 to 10 carbon atoms.;Also provided are novel 15-acyl prostaglandins and a process for the preparation of 15-acyl prostaglandins.