Bordetella pertussis, are described, as well as the construction of vectors containing the regions, and microorganisms transformed by the vectors.;The promoter regions, or nucleotide fragments thereof, are particularly useful for the regulable or non-regulable expression of genes which code for a protein of interest in a strain of Bordetella. The transformed Bordetella strains are particularly suitable for the development of an effective anti-pertussis vaccine."/> Promoter regions of the genes which code for the pilinic subunits fim2, fim3 and fimx of Bordetella pertussis and their use for the expression of genes which code for a protein of interest
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Promoter regions of the genes which code for the pilinic subunits fim2, fim3 and fimx of Bordetella pertussis and their use for the expression of genes which code for a protein of interest

机译:编码百日咳博德特氏菌菌毛菌素亚基fim2,fim3和fimx的基因的启动子区域及其在表达目的蛋白质编码基因中的用途

摘要

The isolation and characterisation of the promoter regions of the genes which code for the pilinic subunits fim2, fim3 and fimx of Bordetella pertussis, are described, as well as the construction of vectors containing the regions, and microorganisms transformed by the vectors.;The promoter regions, or nucleotide fragments thereof, are particularly useful for the regulable or non-regulable expression of genes which code for a protein of interest in a strain of Bordetella. The transformed Bordetella strains are particularly suitable for the development of an effective anti-pertussis vaccine.
机译:描述了百日咳博德特氏菌的菌毛性亚基fim2,fim3和fimx编码基因的启动子区域的分离和鉴定,以及含有该序列的载体的构建。启动子区域或其核苷酸片段对于在博德特氏菌菌株中编码目的蛋白的基因的可调节或不可调节表达特别有用。转化的博德特氏菌菌株特别适合于开发有效的抗百日咳疫苗。

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