METHOD FOR PREPARATION OF 1-METHYL-5-NITROIMIDAZOLES

摘要

Process for preparing 1-alkyl-5-nitroimidazoles of formula: IMAGE (I) which comprises reacting an alkyl sulphate with an imidazole derivative of general formula: IMAGE (II) in an organic solvent, and then hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), R denotes hydrogen, unsubstituted or substituted alkyl, aryl or cycloalkyl. In the formula (I), R1 denotes alkyl. In the formula (II), X denotes a group which can be removed by hydrolysis or alcoholysis.