Polypeptide, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Antimalaria-Vakzinen und von diagnostischen Ausrüstungen zur Bestimmung von Antisporozoit-Antikörpern

摘要

Synthetic polypeptides constituted by at least two consecutive repeating units of (Asn-Asn-Pro) sequence are powerful immunogens in test animals. The formed antibodies recognize both the synthetic polypeptides and the immuno-dominant epitope of the circumsporozoitic protein of Plasmodium falciparum. Said polypeptides, which can be obtained in pure form, are particularly useful for the preparation of antimalarial vaccines and of diagnostic kits for the determination of malarial affections.