MISCHKRISTALLE AUS INSULIN UND INSULINDERIVATEN VERFAHREN ZUR HERSTELLUNG DIESER MISCHKRISTALLE DIESE MISCHKRISTALLE ENTHALTENDE PHARMAZEUTISCHE MITTEL UND IHRE VERWENDUNG ZUR BEHANDLUNG VON DIABETES MELLITUS

摘要

Mixed crystals composed of (a) unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and (b) least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin and Arg-B31 human insulin and/or Arg2-(B31-32) human insulin. These mixed crystals are obtained by crystallization from aqueous solution within a narrow pH range (from about 5.5 to about 6.9). The mixed crystals show a specific moderately prolonged profile and are suitable for the treatment of diabetes mellitus.