Monoclonal antibodies that recognise glycoproteins having a role in relation to platelet functions. Their application as a diagnostic and therapeutic agent

摘要

The invention relates to monoclonal antibodies, or the ideotypic fragments of these monoclonal antibodies, that recognise antigens involved in the steps of platelet physiology, and especially in platelet secretion and/or adhesion and/or aggregation reactions, and/or adhesion reactions of endothelial cells and/or monocyte-platelet interaction, which antibodies have the capacity to modulate platelet functions or endothelial functions induced by a low concentration of agonists, for example in the presence of 2.5 to 5 mu M ADP, 2 mu g/ml of collagen, 0.016 U/ml of thrombin, and whose capacity for inhibiting platelet functions is considerably reduced or even absent in the presence of high concentrations of agonists, for example in the presence of thrombin concentrations above 0.5 U/ml or collagen concentrations above 10 mu g/ml. It also relates to the diagnostic and therapeutic application of these antibodies.