SEQUENCE OF ANTI-SENSE OLIGONUCLEOTIDES, ANTI-RNA MESSAGE OF TNF ALPHA, PREPARATION METHOD, APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS

摘要

Sequence of antisense oligonucleotides, anti-TNF alpha messenger RNA, of formula (I): BR/ TCA TGG TGT CCT TTG CAG - X BR/ in which X represents a hydrogen, a sequence from 1 to 17 oligonucleotides in free form, alkylated, sulphurized or derivatives of poly L-lysine, method of preparation, application as a medicament and pharmaceutical compositions containing this new sequence.