6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides, pharmaceutical compositions, and processes of making

摘要

6-Sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and 3 and 7 deaza and 8 aza derivatives thereof of structure: ##STR1## wherein Z is H or --NH.sub.2 ;P PX is --S--NH.sub.2, ##STR2## T is C--H, G is N and Q is N; or T is C- -H, G is N and Q is C--H; orPPT is N, G is N and Q is C-- H; orPPT is C--H, G is C--H and Q is N;P P Y is H or an -pentofuranose or -pentofuranose of the formula: ##STR3## wherein R.sub.1 and R.sub.2 independently are H, OH, -- O-acyl or ##STR4## or together R.sub.1 and R.sub.2 are ##STR5## and R.sub. 3 and R.sub.4 are H or one of R.sub.3 or R.sub.4 is OH and the other is H; provided that when Y is H, Z is --NH.sub.2 ; and acceptable salt thereof are prepared and are useful as antitumor agents or they are intermediates for compounds which are antitumor agents. The compounds are used to treat an affected warm blooded host by serving as the active ingredients of suitable pharmaceutical compositions.