PRODUCTION OF OPTICALLY ACTIVE 2-METHYLPIPERAZINE

摘要

PURPOSE:To easily produce the subject compound useful as an intermediate for pharmaceuticals such as quinolone antibacterial agent in high optical purity by carrying out the optical resolution of (RS)-methylpiperazine using an optically active N-substituted phenylglycine as an optical resolution agent. CONSTITUTION:The objective compound can be produced by the optical resolution of (RS)-2-methylpiperazine using an optically active N-substituted phenylglycine of formula (R is benzoyl or p-toluenesulfonyl) as an optical resolution agent. The optical resolution is preferably carried out by contacting 1mol of (RS)-2-methylpiperazine with 0.3-1.0mol of N-substituted phenylglycine in a solvent.