MANUFACTURE OF RADIOACTIVE COLLOID MADE FROM HUMAN BLOOD SERUM ALBUMIN

摘要

A colloidal solution of human serum albumin is prepared by mixing an aqueous solution of the latter with a non-ionic surface-active agent and an acid solution of a tin(II) salt, adjusting the pH to 3.5 to 8.0 and heating at a constant temperature between 45 DEG and 100 DEG C. until complete hydrolysis of the tin(II) salt and denaturation of the albumin have taken place; the colloidal solution can also be lyophilized. By treating the solution or the lyophilizate with a 99m Tc-pertechnetate solution, a colloidal preparation is obtained for scintigraphy of the reticuloendothelial system or the lymphatic system. By suitable pH adjustment, the process makes it possible selectively to obtain colloids with a particle size of, for example, 3.0-0.2 or 0.2-0.03 or below 0.03 mu m.