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2,4-DIPHENYL-1,3-DIOXANDERIVATER OG FREMGANGSMAADE TIL FREMSTILLING DERAF SAMT FARMACEUTISK MIDDEL INDEHOLDENDE DERIVATERNE OG DISSES ANVENDELSE TIL FREMSTILLING AF DET FARMACEUTISKE MIDDEL
2,4-DIPHENYL-1,3-DIOXANDERIVATER OG FREMGANGSMAADE TIL FREMSTILLING DERAF SAMT FARMACEUTISK MIDDEL INDEHOLDENDE DERIVATERNE OG DISSES ANVENDELSE TIL FREMSTILLING AF DET FARMACEUTISKE MIDDEL
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机译:2,4-二苯基-1,3-二恶烷衍生物及其制备方法和含有该衍生物的药物及其在制备药物中的用途
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摘要
The invention provides a novel group of 4(Z)-([2,4,5-cis]-2,4-diphenyl-1,3-dioxan-5-yl)hexenoic acids of formula I, wherein X is F, Cl, Br, CF3, CN, CH3O or NO2 and one of Y and Z is hydrogen or fluoro and the other is hydrogen, and their pharmaceutically acceptable salts; together with their pharmaceutical compositions for use in treating a variety of disease conditions. Also provided are methods for the manufacture of novel compounds. Representative compounds are those in which X is 2-cyano or 2-chloro and Y and Z are both hydrogen.
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