首页> 外国专利> PROCESS FOR THE PRODUCTION OF MEDICAL PREPARATIONS WITH REHYDRATING EFFECT, STABILIZED BY THE NEW CRYSTALLIZED FORM OF ALCALI-HYDROGEN-CARBONATE

PROCESS FOR THE PRODUCTION OF MEDICAL PREPARATIONS WITH REHYDRATING EFFECT, STABILIZED BY THE NEW CRYSTALLIZED FORM OF ALCALI-HYDROGEN-CARBONATE

机译:具有新型结晶形式的氢氧化铝-碳酸盐稳定化的具有保湿作用的药物制剂的生产过程

摘要

Dehydrating and simultaneously resalinating medicinal mixts. stabilised by alkali-hydrogen-carbonate(s) of new crystalline forms(s) contain: 90 (Sic-no units provided) sodium, 20 potassium, 80 chloride, 30 hydrogen carbonate, 110 glucose and/or water sol. salts of other metals pref 0.2-2.5 magnesium or calcium (or both in combination). The quoted values are to be dissolved in 1 dm/3 of water. Other overall quantities may be used provided m molar ratios are maintained in the mixts.. Alkali-hydrogen carbonates are present in these mixts. either as an isomorphic crystalline modification of carbon-dioxide satd. sodium-hydrogen-carbonate or as a heteromorphic, non-stoichiometric modification, obtd. from carbon dioxide satd. 0.25-2 mols of potassium-hydrogen-carbonate and 1 mol sodium-hydrogen-carbonate, by compressor. Alkali-hydrogen-carbonates are added to the mix in granular form of 177-841 micro-m. size; The size range of added anhydrous glucose is 250-1000 microns. Foregoing components are mixed with anhydrous alkali-chlorides and opt. flavouring and colouring agents, and are administered dissolved in water.
机译:脱水并同时使药用混合物盐化。由新的结晶形式的碱式碳酸氢氢盐稳定的盐包括:90(未提供SiC的单位)钠,20钾,80氯,30碳酸氢盐,110葡萄糖和/或水溶胶。其他金属的盐,优选0.2-2.5的镁或钙(或两者结合使用)。引用的值应溶解在1 dm / 3的水中。只要在混合物中保持摩尔比,就可以使用其他总量。这些混合物中存在碱式碳酸氢盐。或作为二氧化碳饱和的同构结晶变体。碳酸钠或碳酸氢钠,呈异质性,非化学计量的修饰形式。从二氧化碳饱和。通过压缩机将0.25-2 mol碳酸氢钾和1 mol碳酸氢钠将碱式碳酸氢盐以177-841微米的颗粒形式添加到混合物中。尺寸;添加的无水葡萄糖的尺寸范围是250-1000微米。将上述成分与无水碱金属氯化物混合并选择。调味剂和着色剂,并溶于水施用。

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