Process for the preparation and composition of stabilized cob (II) alamine and cob (II) inamide solutions as starting preparations for the production of medicaments, medical products, food supplements and cosmetics

摘要

The invention includes a process for the preparation and composition of liquid, stabilized cob (II) alamin and cob (II) inamide solutions. These physiological forms of the vitamin B12 group have not hitherto been available in stable solutions for direct use as medicaments, dietary supplements or available for cosmetics. According to the invention, cobalamines and cobinamides of oxidation level III are dissolved in alcohols or aqueous sugar solutions and reduced to oxidation levels II and I with an excess of reducing agents. The reaction takes place by heating these solutions for several minutes and with the exclusion of oxygen and light. The stabilization of the reduced forms is achieved by the excess of reducing agents, the selection of solvents, the reduced water content in these solvents and the exclusion of light and oxygen Manufactured and assembled liquid preparations are suitable as a starting product for the production of medicinal products, medical devices, food supplements and cosmetics.