Nimesulid inclusion cpds. with cyclodextrin - more water-soluble with improved bio-availability than nimesulid alone

摘要

Nimesulid inclusin cpds. (I) with betacyclodextrin alpha,beta and gamma or in their aq. are new and/or have molar ratio nimesulid:cyclodextrin 1:0.5 - 1:15. Pref. the cyclodextrin is of beta-type and. USE/ADVANTAGE - (I) shows improved bioavailability and increase the max. plasma concn. of the nimesulid, which is an antiphlogistic used in the treatment of articular and extraarticular inflammations and is very sparingly soluble and of low bioavailability. (I) have analgesic and antiphlogistic properties and are well soluble in water thus ensuring that the nimesulid is more rapidly resorbed. Suitable unit doses contain 20-150 mg (I). (9pp Dwg.No.0/3)