COMPOUNDS FOR USE IN SLOWING HAIR LOSS AND FOR INDUCING AND STIMULATING HAIR GROWTH CONTAINING DERIVATIVES OF ALKYL-2-AMINO-4-(OR DIALKYL-2,4) PYRIMIDINE-OXYDE-3 AND NEW COMPOUNDSDERIVED FROM ALKYL-2-AMINO-4-PYRIMIDINE-OXYDE-3

摘要

SPECIFIC The invention relates to a pharmaceuti-than or cosmetic composition to slow hair loss and for inducing and stimulating its growth, containing a compound of formula: (I) wherein R1 denotes a hydrogen atom or an alkyl radi-cal C1-C8; R2 is an alkyl C1-C8 or NHR 3 group in which R3 is a hydrogen atom or -COOR 4, R 4 representing an alkyl radi-cal C1-C4; X denotes a group , -OR9 Or -SR10, in which R5 and R6 represent a hydrogen atom, an alkyl radical C1-C12, optionally substituted alkenyl, C2-C12, C3-C10, aralkyl or aryl, or R5 and R6 form with the nitrogen atom to which they are attached a saturated heterocycle or unsaturated; R9 is an alkyl radical C1-C12 even-optionally substituted, alkenyl C2-C12 cycloalkyl, C3-C10, C7-C12-bly or any substituted phenyl; R10 is the same as R9; Y denotes an oxygen atom or a group OSO3 ?; or one of its addition cosmetically or pharmaceutically-acceptable acid salts. The composition of the invention is halogen, linear alkenyl, C2-C12, cycloalkyl or C3-C10 aryl or aral-kyle the formula: or n is 0 to 4; and R7 and / or R8, independently of one another, denote a hydrogen atom, an alkyl group or lower alkoxy C1-C6 alkyl or trifluoromethyl radical; or R5 and R6 together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocycle selected from the group consisting of Aziri-dino groups, azetidino, pyrrolidino, piperidino, hexamethyleneimino, heptamethyleneimino, octamethyleneimino, tetra-hydropyridino, dihydropyridino, pyrrole, pyrazole, imida-zole, triazole, alkyl-4 piperazino, morpholino and thiamor -pholino; (Ii) a group -OR 9, wherein R 9 denotes an alkyl radical C1-C12, linear or branched, even-optionally substituted by at least one halogen, alkenyl C2-C12, cycloalkyl C3 radical C10, aralkyl in C7-C12, a phenyl radical optionally substituted by one or two groups which, for use in topical application, especially for the treatment and prevention of falling hair-like and in particular alopecia areata , alopecia and desquamating dermatitis and stimulation of regrowth.