STEREOCONTROLLED PRODUCTION OF HYDROXYESTER, HYDROXYAMIDE, AND LACTONE COMPOUNDS FROM CHIRAL ALPHA-AMINO ALDEHYDES

摘要

75/GHB17 18259 TITLE OF THE INVENTION STEREOCONTROLLED PRODUCTION OF HYDROXYESTER, HYDROXYAMIDE AND LACTONE COMPOUNDS FROM CHIRAL .alpha.-AMINO ALDEHYDES A process for stereocontrolled preparation of a medicinally significant hydroxyester, hydroxyamide or lactone compound of structural formula: comprises the addition of homoenolate equivalents to chiral .alpha.-amino aldehydes. The hydroxyester, hydroxyamide, or lactone reaction products arc useful as inhibitors of the HIV protease or of renin, or as intermediates in the preparation of inhibitors of the HIV protease or renin.