Research Progress of Aldehyde Ketone Reductase for Asymmetric Catalysis of Chiral Compounds

摘要

Compared with chemical synthesis, biosynthesis of chiral compounds has the advantages of mild reaction condition, high selectivity and environmental protection. It has a broad development prospects. As the development of biotechnology, gene engineering and enzyme engineering, the aldehyde ketone reductase catalytic activity, stereoselectivity and tolerance will be improved significantly. At the same time, the molecular mechanics model and the computer simulation technology will become more matured. It will have a more profound understanding of enzyme reaction mechanisms guiding the rational design for asymmetric synthesis.