METHOD OF PRODUCTION OF SOPHOROSIDES BY FERMENTATION WITH FED BATCH SUPPLY OF FATTY ACID ESTERS OR OILS

摘要

In a fed-batch method of production of a sophoroside composition, at least one strain of Candida bombicola or Candida apicola is cultured and the said cultured strain is exposed in a reaction zone to excess sugar and a fed-batch supply of at least one suitable substrate, at a feed rate into the reaction zone of between 0.01 and 4 grammes per hour and per litre of initial reaction volume, the feed period being such that the residual concentration of the said substrate in the reaction zone is maintained at 18 grammes per litre of initial reaction volume at most during the said feed period. The resulting sophoroside composition is recovered.