Use of ergoline derivatives for the treatment of diseases associated with bone demineralization

摘要

A method of inhibiting bone demineralization comprising administration of an effective amount of a compound having the formula where   X is CH or N;   Y is O or S;   R¹ is 2-propenyl, C₁-C₃ alkyl, benzyl or substituted benzyl where the substitutents are one or two of the same or different and are selected from methyl, ethyl, methoxy, ethoxy, hydroxy, chloro, bromo, or fluoro;   R₂ is C₂-C₃ alkyl, allyl or cyclopropylmethyl;   R³ and R⁴ are both hydrogen or combine to form a carbon-carbon bond; and pharmaceutically acceptable acid addition salts thereof to a mammal requiring bone demineralization inhibition.