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the physiological activity of the peptide and the effectiveness of the two control system containing calcium metabolism.
the physiological activity of the peptide and the effectiveness of the two control system containing calcium metabolism.
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机译:肽的生理活性和含有钙代谢的两个控制系统的有效性。
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摘要
A novel physiologically active peptide having the amino acid sequence (I) wherein X1 stands for Ser-Thr or Thr-Ser, X2 stands for Met, Gly, Ala, Val, n-Val, Pro, Leu, n-Leu, Ile, Phe or α-aminolactic acid, X3 stands for Asp or Glu, X4 stands for Leu-Gln-Thr, Gln-Thr, Leu or Gly-Gln-Thr, X5 stands for Val-Gly-Ala or Ser-Gly-Thr, R stands for H, NH2, N-acyl or N-aklyl, X6 sands for CO-NH or NH-CO, X7 stands for an amino acid sequence at the 2- to 6-positions of native calcitonin, or a substitution, deletion or addition derivative thereof, having 0 to 6 amino acids, X8 stands for an amino acid sequence at the 8- to 32-positions of native calcitonin, or a substitution, deletion or addition derivative thereof, and each of n1 and n2 is an integer or 1 to 19 and n1 + n2 is 2 to 20, or a pharmacologically acceptable salt thereof, and a calcium metabolism-regulating agent comprising, as an effective ingredient, the above-mentioned peptide or salt.
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