Isolated nucleic acid molecule, process for identifying a nucleic acid molecule encoding a mammalian endoglucuronidase polypeptide, expression vector, isolated heparanase peptide, recombinant or isolated polypeptide, antibody molecule, process for identifying a modulator of heparanase activity, use of a sulfated oligosaccharide, a sulfonate or hspg comprising the same, processes for treating a physiological or medical condition in a human or animal subject in which the heparanase activity in that subject is high, to intensify the healing of wounds in a subject human or animal and to diagnose a physiological or medical condition associated with overexpression of heparanase, e, cell

摘要

"NUCLEIC ACID ISOLATED MOLECULE, PROCESS FOR IDENTIFYING A NUCLEIC ACID MOLECULE BY CODING A MAMMALIAN ENDOGLUCURONIDASE POLYPEPTIDE, HEPARANEOUS, HYPERANEOUS, HYPERANEATED, HYPOTHOLIC, HYPERANEOUS, HYPOTHOLIC, HYPOTHOLIC, HYPOTHOLIC , USE OF A SULPHATED OLIGOSACARID, A SULPHONATE OR HSPG UNDERSTANDING THE SAME, PROCESSES FOR TREATING A PHYSIOLOGICAL OR MEDICAL CONDITION IN A HUMAN OR ANIMAL SUBJECT IN WHICH THE HEPARANASE ACTIVITY IN THE SUBJECT IS SUBJECT TO EYES, IS SUFFERED IN A SUBJECT TO EYES, HUMAN OR ANIMAL SUBJECT AND TO DIAGNOSE A PHYSIOLOGICAL OR MEDICAL CONDITION ASSOCIATED WITH HEPARANASE OVEREXPRESSION, AND, CELL "The present invention relates to enzymes, polypeptides and isolated or recombinant peptides of human endoglucuronidase, in particular heparas of human heparas, particularly human heparas, , murine and rat, to coded genetic sequences the same, and their uses, for example, in the determination and characterization of chemical compounds, proteins, polypeptides, small molecules and macromolecules capable of inhibiting metastasis, angiogenesis, angioplasty-induced restenosis, atherosclerosis, inflammation, promoting wound healing and , otherwise, modulate physiological processes that involve heparanase cleavage from heparan sulfate. The invention also relates to a process for altering, modifying or otherwise modulating the level of expression of mammalian heparanase in a cell. Another aspect of the invention relates to immunoreactive molecules capable of binding to, and / or inhibiting, mammalian heparanase. In particular monoclonal antibodies. A further aspect of the invention concerns the use of heparanase as an agent to promote wound healing processes.