STRAIN OF BACTERIA NEISSERIA MENINGITIDIS OF SEROGROUP B - A PRODUCER OF CAPSULAR POLYSACCHARIDES AND POLYSACCHARIDE-PROTEIN COMPLEX

摘要

the invention u043eu0442u043du043eu0441u0438u0442u0441u00a0 to biotechnology 'ai and u043au0430u0441u0430u0435u0442u0441u00a0 u043fu043eu043bu0443u0447u0435u043du0438u00a0 new strain of bacteria Neisserla meningitidfs - u043fu0440u043eu0434u0443u0446u0435u043du0442u0430 u043au0430u043fu0441u0443u043bu044cu043du043eu0433u043e in u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u0430 and u043fu043eu043bu0438u0441u0430u0445u0430' u0440u0438u0434u043du043e - protein the complex and can be used in the manufacture of meningococcus is u043au043eu0432u044bu0445 preparations. purpose u0438u0437u043eu0431u0440u0435u0442u0435u043du0438u00a0 u00a0u0432 - u043bu0439u0432u0442u0441u00a0 a strain of bacteria N.meningitidls u0441u0435u0440u043eu0433u0440u0443u043fu043fu044b no. 125 (u043au043eu043bu043bu0435u043au0446u0438u00a0 u0433u0438u0441u043a. los angeles.u0442u0430u0440u0430u0441u0435u0432u0438u0447u0430), actively u043fu0440u043eu0434u0443u0446u0438u0440u0443u044eu0449u0435u0433u043e in either. solution the largest molecules - u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u0430 emitted from biomass of strain, 1.5 times higher than when using the known strains.the level of antibodies to u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u0443 meningococcus u0441u0435u0440u043eu0433u0440u0443u043fu043fu044b in u0441u044bu0432u043eu0440u043eu0442u043au0430u0445 animals received half of the proposed strain u043cu0435u043du0438u043du0433u043eu043a u0438u0441u0430u0445u0430u0440u0438u0434u043du043e - u0431u0431u0435u043bu043au043eu0432u043eu043cu0443 oka, 3 times higher than similar antibodies in the u0441u044bu0432u043eu0440u043eu0442u043au0430u0445 received by u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u043du043e - u0431u0435u043bu043au043eu0432u043eu043cu0443 of known strain. 3, table 2).the invention u043eu0442u043du043eu0441u0438u0442u0441u00a0 biotechnology and u043au0430u0441u0430u0435u0442u0441u00a0 u043fu043eu043bu0443u0447u0435u043du0438u00a0 new strain of bacteria Neisserla menlngltldis - u043fu0440u043eu0434u0443u0446u0435u043du0442u0430 u043au0430u043fu0441u0443u043bu044cu043du043eu0433u043e! in u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u0430 and policy - u0445u0430u0440u0438u0434u043du043e - protein complex and can be used in the manufacture of menin u0433u043eu043au043eu043au043au043eu0432u044bu0445 preparations.the majority of wild strains of meningococcus u0441u0435u0440u043eu0433u0440u0443u043fu043fu044b in produced u0433u0440u0443u043fu043fu043eu0441 - u043fu0435u0446u0438u0444u0438u0447u0435u0441u043au0438u0439 capsule either (- either) - u0441u0438u0430u043bu043eu0432u0443u044e acid in a minor quantities that do not u043fu043eu0437u0432u043eu043bu00a0u0435u0442 ip with these strains in u043au0430u0447u0435u0441u0442u0432u0435u043fu0440u043eu0434u0443u0446u0435u043du0442u043eu0432 in u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u0430 and u043fu043eu043bu0438u0441u0430u0445u0430 - u0440u0438u0434u043du043e - protein u043au043eu043cu043fu043bu0435u043au0441u0430.u0438u0437u0432u0435u0441u0442u043du044b strains of bacteria Neisserla meningltidls u0441u0435u0440u043eu0433u0440u0443u043fu043fu044b - producers u043au0430u043fu0441u0443u043bu044cu043du043eu0433u043e u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u0430.lack of these strains u00a0u0432u043bu00a0u0435u0442u0441u00a0 small out - u043fu043eu043bu0438u0441u0430u0445u0430u0440u0438u0434u0430 that u0432u044bu0440u0430u0436u0430u0435u0442u0441u00a0 in low levels of antibodies to the half u0438u0441u0430u0445u0430u0440u0438u0434u0443 mice immunized 10 micrograms policy u0445u0430u0440u0438u0434u043du043e - protein antigen u0432u043du0443u0442u0440u0438u0431u0440u044eu0448u0438u043du043du043e.u0446u0435u043bu044c u0438u0437u043eu0431u0440u0435u0442u0435u043du0438u00a0 is a strain of bacteria Neisserla menlngltidis u0441u0435u0440u043eu0433u0440u0443u043fu043fu044b in ns 125 (u043au043eu043bu043bu0435u043au0446u0438u00a0 u0433u0438u0441u043a. u043b.u0430.u0442u0430u0440u0430u0441u0435u0432u0438 - XIu043e 0000u044c. oh