METHOD FOR PREPARATION N-(1-ADAMANDYL)-N-(2,4-DINITROPHENYL)-3-BROM -4-(N-R-PHENYL)-2,4-DIOXOBUTANE AMIDRASONES

摘要

the invention u043au0430u0441u0430u0435u0442u0441u00a0 u0430u043cu0438u0434u0440u0430u0437u043eu043du043eu0432, in particular u043fu043eu043bu0443u0447u0435u043du0438u00a0 m - (1 - u0430u0434u0430u043cu0430u043du0442u0438u043b) - m g (2.4 - u0434u0438u043du0438u0442u0440u043eu0444u0435u043du0438u043b) - 3 - bromine - 4 - (p - r - u0444u0435u043du0438u043b) - n - r - C6H4C (- 0) ch (br) c (0) c (- n, - nh - 2.4 - flnu043du0438u0442u0440u043e - u0441u0435u043du0437 - 1u043cu043d - u0430u0434u0430u043cu0430u043du0442u0438u043b), where r u0441u043du0437. ci, which has u043fu0440u043eu0442u0438u0432u043eu043cu0438u043au0440u043eu0431u043du043eu0439 activity and can be used as medicines.the development mode of the u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0430u043cu0438u0434u0440u0430u0437u043eu043du043eu0432 with high u043fu0440u043eu0442u0438u0432u043eu043cu0438u043au0440u043eu0431u043du043eu0439 activity. the mixture is at u044du043au0432u0438u043cu043eu043bu0435u043au0443u043bu00a0u0440u043du044bu0445 quantities (1 - u0430u0434u0430u043cu0430u043du0442u0438u043b) u0438u043cu0438u043du043e - 4 - bromine - 5 - (p - r - u0444u0435u043du0438u043b) - 2.3 - u0434u0438u0433u0438u0434u0440u043e - 3 - u0444u0443u0440u0430u043du043eu043du0430 and 2,4 - u0434u0438u043du0438u0442u0440u043eu0444u0435u043du0438u043bu0433u0438u0434u0440u0430u0437u0438u043du0430 in u0434u0438u043eu043au0441u0430u043du0435 in to u043cu043du0430u0442u043du043eu0439 temperature for 1.5 - 2 hours, followed by the allocation of a trust product. exit 76%, u0442.u043fu043b.152 - 153 & deg; c u0434u043bu00a0 C27H28BrNs06, exit 71%, u0442.u043fu043b. 132 - 133 u0434u043bu00a0 C26H25BrCINs06. new u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 have u043fu0440u043eu0442u0438u0432u043eu043cu0438u043au0440u043eu0431u043du043eu0439 activity in 2 - 4 times the activity u044du0442u0430u043au0440u0438 - dino lactate. 3, table 2). (l, c