Candida acid protease inhibiting compounds

摘要

Compounds which inhibit Candida acid protease are disclosed which have the formula: ##STR1## wherein R.sub.1 is loweralkyl, loweralkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, arylalkyl or (heterocyclic)alkyl;PPR. sub.2 is loweralkyl, cycloalkylalkyl or arylalkyl;PPR.sub. 3 is --OH or --NH. sub.2 ;PPR.sub.4 isPP (a) --CH(OH)--R.sub. 5 wherein R.sub.5 is loweralkyl, cycloalkyl or cycloalkylalkyl orP P(b) --CH.sub.2 CH(R.sub.6)C(O)NHR. sub.7 wherein R.sub.6 is loweralkyl and R.sub.7 is loweralkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxyalkyl, alkoxyalkyl, thioalkoxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, cyanoalkyl or (heterocyclic)alkyl; andPPA is ##STR2## wherein R.sub.8 is arylalkyl, B is -- C(O) or --S(O).sub.2 -- and R.sub.9 is aryl, arylalkyl, heterocyclic or (heterocyclic)alkyl; or ##STR3## wherein R.sub. 10 is arylalkyl and R.sub. 11 is (a) --C(O)R.sub.12 wherein R.sub.12 is alkoxy, arylalkoxy, aryl, arylalkyl, heterocyclic or (heterocyclic)alkyl or (b) --S(O).sub.2 --R. sub.13 wherein R.sub.13 is aryl, arylalkyl, heterocyclic or (heterocyclic) alkyl; or a pharmaceutically acceptable salt, ester or prodrug thereof.