首页> 外国专利> Partially coated C.sub.10 -C.sub.20 fatty acid salts of peptides having molecular weights up to about 5,000

Partially coated C.sub.10 -C.sub.20 fatty acid salts of peptides having molecular weights up to about 5,000

机译:分子量不超过5,000的多肽的部分包被的C10-C20脂肪酸盐

摘要

The invention relates to compositions for the parenteral administration of an essentially uniform and continuous amount of a peptide, which has a molecular weight of up to about 5,000, over an extended period of time. The peptide composition comprises a compacted and partially coated C.sub.10 -C.sub.20 fatty acid salt of the peptide. Examples of peptides useful in the invention includePPhis- D-trp-ala-trp-D-phe-lys-NH.sub.2,PPbradykinin, luteinizing hormone releasing hormone, growth releasing factor and poly-l- lysine. The invention also relates to the preparation and administration of said peptide compositions.
机译:本发明涉及在延长的时间内肠胃外给药基本上均匀和连续量的肽的组合物,该肽的分子量高达约5,000。所述肽组合物包含所述肽的压实的且部分包被的C 10 -C 20脂肪酸盐。可用于本发明的肽的例子包括:P P缓激肽,促黄体生成激素释放激素,生长释放因子和聚赖氨酸。本发明还涉及所述肽组合物的制备和给药。

著录项

  • 公开/公告号US5137874A

    专利类型

  • 公开/公告日1992-08-11

    原文格式PDF

  • 申请/专利权人 AMERICAN CYANAMID CO.;

    申请/专利号US19910661787

  • 发明设计人 SUSAN M. CADY;RICHARD FISHBEIN;

    申请日1991-02-25

  • 分类号A61K37/00;A01N37/18;A01N37/12;A61F13/00;

  • 国家 US

  • 入库时间 2022-08-22 05:22:29

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