REMEDY FOR DISEASE ACCOMPANYING ABNORMAL ACCUMULATION OF COLLAGEN

摘要

PURPOSE:To obtain a remedy for diseases accompanying abnormal accumulation of collagen, having procollagenase-production promoting action and effective in ameliorating hepatic disorder caused by hepatic fibrosis by using a specific compound as an active component. CONSTITUTION:The objective agent contains a compound of formula (R1 and R2 are H or methyl) as an active component. The compound of formula is e.g. L-serine, DL-serine, N-methyl-L-serine, N-methyl-DL-serine or N,N-dimethyl- L-serine. The remedy of formula can be administered to person by oral adminis tration or parenteral administration such as injection or transcutaneous adminis tration. It has low toxicity and low skin-stimulation. The administration amount of the remedy is preferably 30-1,000mg/dose for diseases characterized by abnor mal accumulation of collagen to organs (e.g. hepatic fibrosis or pulmonary fibrosis) in the case of systemic administration by oral administration or injec tion and is 1-50mg/dose for diseases characterized by abnormal accumulation of collagen to epithelium (e.g. keloid or hypertrophic cicatrix) by transcutaneous administration to the diseased part.