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2'-deoxy-5-fluorouridine derivatives, process for their preparation, anticancer agents containing such compounds and use of such compounds for the preparation of anti-cancer agents
2'-deoxy-5-fluorouridine derivatives, process for their preparation, anticancer agents containing such compounds and use of such compounds for the preparation of anti-cancer agents
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机译:2'-脱氧-5-氟尿苷衍生物,其制备方法,含有这类化合物和使用这些化合物的抗癌剂的制备抗癌剂
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摘要
This invention relates to a 5-fluorouracil derivative represented by the formula CHEM wherein Ry is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group CHEM wherein R1 and R2 are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group RxOCO- on the phenyl ring, or a group -(A)nB, Rx fix being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from nitrogen, oxygen and sulfur and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that when R1 is a hydrogen atom or acyl group, R2 is not a hydrogen atom or acyl group; to a process for preparing the same; to an anticancer composition comprising an effective amounts of the same; and to use of the same for preparation of an anticancer composition.
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