首页>
外国专利>
METHOD FOR ENHANCING THE IMMUNOTHERAPEUTIC ACTIVITY OF LYMPHOCYTES AND AGENTS AND KITS CONTAINING LYMPHOCYTES OF ENHANCED ACTIVITY
METHOD FOR ENHANCING THE IMMUNOTHERAPEUTIC ACTIVITY OF LYMPHOCYTES AND AGENTS AND KITS CONTAINING LYMPHOCYTES OF ENHANCED ACTIVITY
展开▼
机译:增强淋巴细胞和代理商以及包含增强活性的淋巴细胞的试剂盒的免疫治疗活性的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is directed to a method of increasing the in vivo immune response of lymphocytes by stimulating the lymphocytes in vitro in the presence of an anti-CD3 monoclonal antibody for less than about 24 hours to form stimulated lymphocytes; infusing the stimulated lymphocytes into a tumor-bearing mammal; and administering IL-2 to the mammal. As a result of this method, the anti-CD3 stimulated lymphocytes display enhanced immunotherapeutic, e.g., cytotoxicity or lymphokine production, in vivo as represented by a decrease in the number of tumors by at least about 20%.
展开▼