method for preparation of a preparation method for the preparation of a compound vascoludilatatoire operation suitable for use in this method

摘要

1455502 Amino-esters derived from 2,6-dialkyl - 4 - phenyl - 4,4 - dihydropyridines YAMANOUCHI PHARMACEUTICAL CO Ltd 11 Feb 1974 [20 Feb 1973 3 March 1973 20 April 1973 11 May 1973 17 May 1973 24 July 1973 29 Nov 1973 (2)] 06045/74 Heading C2C The invention comprises compounds of formula and their non-toxic salts, wherein R and RSP4/SP are each H or alkyl; RSP1/SP and RSP2/SP are each alkyl; RSP3/SP is (possibly substituted) Ph or aralkyl; RSP5/SP is alkyl, alkoxy, alkoxyalkoxy or RSP6/SP is NO 2 or CF 3 ; and A is alkylene, each of the foregoing alkyl, alkoxy and alkylene groups containing 1-6 C atoms. In examples, these compounds are prepared by (1) reacting together RSP6/SPC 6 H 4 CHO, an ester (A) of the acid and an ester (B) of the acid RSP1/SPC(NR) : CHCO 2 H, one of these esters being esterified with RSP5/SPOH and the other with RSP3/SPRSP4/SPNAOH, with the following possible variations-(a) ester (B) may be formed in situ from ester (A) and RNH 2 , (b) the RSP6/SPC 6 H 4 CHO and ester (A) may be replaced by a corresponding ester of (2) reacting HNRSP3/SPRSP4/SP with (e.g.) the methyl or isopropyl ester of 3-(2-chloroethoxycarbonyl)-2,6- dimethyl - 4 - (3 - nitrophenyl) - 1,4 - dihydropyridine-5-carboxylic acid Therapeutic compositions having musculotropic spasmolytic and cerebral vascular dilator activity comprise compounds of the above formula and may be administered orally and parenterally.