PEPTIDES WITH CYSTEINE RESIDUE OR DIMERS THEREOF WITH INSULIN ACTIVITY AND PHARMACEUTICAL COMPOSITIONS

摘要

Short peptides of the formula I X-Y-A-B-C-Cys-D-E (I in which A and B are an amino acid or a covalent bond, C and D are an amino acid or a substituted amino acid, E is a modified or unmodified amino acid or a covalent bond, X is a radical or hydrogen and Y is leucine or a covalent bond, or dimers of the peptides of the formula I with cystine as dimerisation component, the stereoisomeric forms thereof where appropriate or their physiologically tolerated salts, the preparation thereof, and their use for the treatment of diabetes mellitus are described.