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METHOD OF OBTAINING STABILIZED PREPARATIONS OF CONTROLLABLE RELEASE IN AN ACRYLIC POLYMER CASING AND STABILIZED PREPARATIONS OF CONTROLLABLE RELEASE
METHOD OF OBTAINING STABILIZED PREPARATIONS OF CONTROLLABLE RELEASE IN AN ACRYLIC POLYMER CASING AND STABILIZED PREPARATIONS OF CONTROLLABLE RELEASE
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机译:在丙烯酸聚合物套管中获得稳定释放的可控制剂的方法和稳定释放的可控制剂
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摘要
A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of an acrylic polymer is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of the plasticized acrylic polymer and then curing the coated substrate at a temperature above the glass transition temperature of the plasticized acrylic polymer, until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.
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